In a large clinical trial, 1818 smokers were randomized to 12 week treatment of Commit lozenge or placebo. Nearly half of COMMIT users remained smoke free at 6 weeks. Commit 4 mg significantly reduces weight gain associated with quitting1 * which can be a barrier to successful quit attempts.2 Reduction in weight gain occurs only during the 12 week Commit 4 mg regimen. Leading smoking cessation experts believe that time to first cigarette is a better measure of dependence compared with number of cigarettes smoked.1 References: 1.Shiffman S, Dresler CM, Hajek P, Gilburt SJA, Targett DA, Strahs KR. Efficacy of a nicotine lozenge for smoking cessation. Arch Intern Med. 2002; 162:1267-1276. 2. Fiore MC. Bailey WC, Cohen SJ, et al. Clinical Practice Guideline: Treating Tobacco Use and Dependence. Rockville, MD: Public Health Service, US Department of Health and Human Services; June 2000. †Results with Commit® 4mg. Commit® 2mg 46%, placebo 30% (P<0.001 for both 4mg and 2mg vs. placebo) at 6 weeks. Commit 4mg 15%, Placebo 6%, Commit 2mg 18%, Placebo 10% at 1 year. * Results with Commit 4mg lozenge and during treatment period only. Mean change in body weight (kg) Commit 4 mg 1.27, placebo 2.30 at 6 weeks (P<0.001) and Commit 4 mg 2.67, placebo 3.40 at 12 weeks (P=0.04).